Ketone bodies: More than energy, they are powerful signaling metabolites that clean up damaged proteins

Ketone bodies are not just about energy. These metabolites are powerful signaling molecules that have profound effects on the proteome and protein quality control in the brain. Scientists, working in mouse models of Alzheimer's disease and aging, and in the nematode C. elegans, reveal the ketone body -hydroxybutyrate interacts directly with misfolded proteins, altering their solubility and structure so they can be cleared from the brain through the process of autophagy. The work hints at a tantalizing possibility -- ketone bodies as a global treatment to restore the integrity of the proteome, addressing one of the key hallmarks of aging.


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Cardiovascular drugs may reduce dementia risk

Common cardiovascular drugs are linked to a lower risk of dementia in older age, according to a new study.


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23 Best Gifts for Caregivers: Practical Luxuries You’ve Never Thought Of

Date published: 2024-12-01 Looking for a gift for a hard-working family caregiver? To help express your thanks and appreciation, youRead More


The post 23 Best Gifts for Caregivers: Practical Luxuries You’ve Never Thought Of appeared first on DailyCaring.


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Clinical trial reveals twice-yearly injection to be 96% effective in HIV prevention

Recent results from a recent clinical trial indicate that a twice-yearly injection of Lenacapavir offers an overall 96% reduced risk of acquiring HIV. This makes Lenacapavir significantly more effective than the standard daily oral PrEP (pre-exposure prophylaxis).


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Study identifies potential new drug for Parkinson's-related cognitive decline, dementia

A recently published study found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson's disease and related disorders.


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